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2025年第一梯次中心論文獎勵

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王焰增

Caffeine as a stabilizer in Novel Hydroxypropyl-β-cyclodextrin/Axitinib Drug-Delivery Systems: A computational study

Wang, Yeng-Tseng*; Chen, Tun-Chieh

March 2025

Computational and Theoretical Chemistry

石啟仁

Antimicrobial properties of bimetallic- containing mesoporous bioglass against Enterococcus faecalis

Kin-Weng Wong, Yi-Ju Li, Hui-Ci Yang, Chi-Sheng Chien, Li-Ting Kao, Ting-Sheng Lin, Tsung-Ying Yang*, Chi-Jen Shih*

2025 Jan;20(1):510-521.

Journal of Dental Sciences

林韋佑

Sustainable Synthesis of Polyfluoro-Pyrimido [1,2-] Benzimidazole Derivatives Using a Tandem Strategy─Ultrasound and an Integrated Continuous Flow System.

Vijay Thavasianandam Seenivasan, Nian-Qi Chen, Karthick Govindan, Alageswaran Jayaram, Yu-Chen Lin, Chien-Hung Li, Wei-Yu Lin*

2025 Mar 21;90(11):4018-4027.

The Journal of Organic Chemistry

陳喧應

Evolution of aluminum aminophenolate complexes in the ring-opening polymerization of ε-caprolactone: electronic and amino-chelating effects

Prasanna Kumar Ganta, Fei Huang, Taoufik Ben Halima, Rajiv Kamaraj, Yu-Ting Chu, Hsi-Ching Tseng, Shangwu Ding, Kuo-Hui Wu* and
Hsuan-Ying Chen*

2025 Jan 2;54(2):511-532.

Dalton Transactions

石啟仁

Assessment of silver-copper co-loaded mesoporous bioactive glass as an advanced pulp-capping material

Jung-Chang Kung, Hui-Ci Yang, Tsung-Ying Yang*, Chi-Jen Shih*

2025 Feb:153:105549.


Journal of Dentistry

柯宏慧

Sustainable extraction of bioactive compounds with antioxidant and tyrosinase inhibitory activities from Phyla nodiflora via Microwave hydrodiffusion and gravity method

Liu, Wan-Yi ; Hsiao, An-Kai; Wu, Yu-Tse*;Ko, Horng-Huey*.

April 2025

Sustainable Chemistry and Pharmacy

鄭添祿

Development of a tumor-region-selective activation monoclonal antibody targeting the 4-1BB receptor for enhanced therapeutic efficacy and safety

Tzu-Yi Liao, Yen-Ling Liu, Chiao-Yun Chen, Bing-Tsung Wu , En-Shuo Liu , Shih-Ting Hong, Bo-Cheng Huang , Yi-An Cheng, Michael Chen, Kuo-Hsiang Chuang, Wen-Wei Lin, Chih-Hung Chuang, Fang-Ming Chen, Kai-Wen Ho*, Tian-Lu Cheng

2025 May;305(Pt 2):141003.


International Journal of Biological Macromolecules

鄭添祿

Targeted internalization and activation of glycosidic switch liposomes by a biological macromolecule mPEGxEphA2 increases therapeutic efficacy against lung cancer

Kai-Wen Ho, Yen-Ling Liu, Bo-Cheng Huang, Shih-Ting Hong, Shih-Hung Yang, Tzu-Yi Liao, En-Shuo Liu, Yu-Tung Chen, Yi-Zhong Huang, Yu-Lin Leu, Chiao-Yun Chen, Bing-Mae Chen, Steve R Roffler*, Tian-Lu Cheng*

2025 Apr:300:140138.


International Journal of Biological Macromolecules

鄭添祿

Impact of Pre-existing Anti-polyethylene Glycol Antibodies on the Pharmacokinetics and Efficacy of a COVID-19 mRNA Vaccine (Comirnaty) In Vivo

Yen-Ling Liu, Tzu-Yi Liao, Kai-Wen Ho, En-Shuo Liu, Bo-Cheng Huang, Shih-Ting Hong, Yuan-Chin Hsieh, Mu-Shen Chang, Bing-Tsung Wu, Fang-Ming Chen, Steve R Roffler, Chiao-Yun Chen*, Yuan-Chieh Yang*, Tian-Lu Cheng*

2024 Dec 11:28:0112.

Biomaterials Research

李建興

Repurposing of the Antipsychotic Trifluoperazine Induces SLC7A11/GPX4- Mediated Ferroptosis of Oral Cancer via the ROS/Autophagy Pathway

Sheng-Chieh Tsai, Po-Chih Chang#, Yu Tong Lin, Po-Tsang Huang, Jeff Yi-Fu Chen, Chang-Shen Lin, Bin-Nan Wu, Hui-Min Chang, Wan-Ju Wu, Chi-I Chang, Chien-Hsing Lee*

2024 Nov 11;20(15):6090-6113.

International Journal of Biological Sciences

李偉鵬

Precise Methylation Detection of Tumor Suppressor Gene Promoters by Magnetic Enrichment and Nano Silver Adduct–Promoted Surface-Enhanced Raman Scattering

Shubham Singh, Yu-Wei Li, Wen-Jyun Wang, Yu-Cheng Chang, Yi-Hsin Chien*, and Wei-Peng Li *

2025 Mar;21(11):e2407517.

Small

李偉鵬

Scalable liposomes functionalization via membrane lipid exchange mechanisms

Long, Xizi; Kataoka-Hamai, Chiho; Ho, Chia-Lun, Huang, Wei-Lun; Kuo, Yi-Ho; Yang, Li-Ting ; Li, Wei-Peng* ; Okamoto, Akihiro*

April 2025


Nano Today

李偉鵬

Redox Disruption Using Electroactive Liposome Coated Gold Nanoparticles for Cancer Therapy

Ying-Chi Chen#, Li-Chan Chang#, Yan-Ling Liu#, Ming-Che Chang, Yin-Fen Liu, Po-Ya Chang, Divinah Manoharan, Wen-Jyun Wang, Jia-Sin Chen, Hsueh-Chun Wang, Wen-Tai Chiu*, Wei-Peng Li*, Hwo-Shuenn Sheu*, Wen-Pin Su*, and Chen-Sheng Yeh*

2025 Apr 5;16(1):3253.

Nature Communications

李偉鵬

Utilizing Electron-Sink-Enhanced Nanoshells for Amplified Nanoplasmonic SERS-Based In Situ Detection of Cancer Cells, Linking Signal Enhancement with Cellular Damage

Liu-Chun Wang#, Yu-Cheng Kou#, Yen-Ting Kuo#, Kai-Lin Chang, Ying-Chi Chen, Wen-Jyun Wang, Ming-Yuan Hung, Fang-Yi Hsu, Pooja Aich, Yu-Wei Lin, Chia-Hao Su, Divinah Manoharan, Yi-Hsin Chien*, Wei-Peng Li*, Hong-Kang Tian*, Chen-Sheng Yeh*

2025 May;37(20):e2417950.

Advanced Materials

2025年第二梯次中心論文獎勵

獲補助之中心成員

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吳寶珠

A novel approach of polyvinyl alcohol/acrylic acid based hydrogels for controlled delivery of diclofenac sodium

Muhammad Suhail*, Syed Faisal Badshah, I-Hui Chiu, Arif Ullah, Arshad Khan, Hamid Ullah, Noorah Saleh Al-Sowayan, Ming-Jun Tsai, Pao-Chu Wu*

2025;26(4):477-489.

Current Pharmaceutical Biotechnology

吳寶珠

Designing of environmentally ph‑responsive antibacterial hydrogels of polyvinyl pyrrolidone for controlled release of tetracycline

Muhammad Suhail, Naila Jabeen, Susu An, Perumal Ramesh Kannan, Abdul Wahab, Bushra Kiran, Alamgir, Zahoor Ahmad, Zhang Han*, M. Zubair Iqbal*, Xiangdong Kong*, Pao-Chu Wu*

June,2025

Journal of Saudi Chemical Society

吳寶珠

Preparation of natural polymer-based hydrogels for oral delivery of anti-malarial drug in vitro and cytotoxicity evaluation

Muhammad Suhail, Abdul Wahab, Guiyue Wang, Susu An, Bushra Kiran, Naila Jabeen, M. Zubair Iqbal*, Xiangdong Kong*, Pao-Chu Wu*

2025 Aug 26;15(37):30378-30386.

RSC Advances

吳寶珠

Formulation, Characterization, Anti-bacterial, Anti-inflammatory, Anticancer, and Cytotoxicity Assessment of Collagen/Gelatin-based Hydrogels as Controlled Drug Release Agents

Muhammad Suhail#, Susu An#, Bushra Kiran, Siru Huang, Abdul Wahab, Shuhui Yang, Xiangdong Kong*, M. Zubair Iqbal*, Pao-Chu Wu*

2025 Sep 14;328(Pt 2):147653.

International Journal of Biological Macromolecules

陳喧應

Comparison of catalytic activities of aluminum complexes with sulfur and oxygen containing ligands for the ring-opening polymerization of ε-caprolactone

Tzu-Yu Lin, Yu-Chi Liou, Taoufik Ben Halima, Shih-Ya Huang, Rajiv Kamaraj, Hsi-Ching Tseng, Shangwu Ding, Hsuan-Ying Chen*, and Chien-Ming Lee*

2025 Sep 16;54(36):13562-13573.

Dalton Transactions

陳喧應

Preparation of antibacterial CO2-based polycarbonate hydrogels with dual cross-linkages for co-loading of antibiotics and hypoglycemic agents and their applications on diabetic wound dressings

Zheng-Ian Lin, Tzu-Hsien Tsai, Guan-Lin Liu, Chih-Yuan Hsu, Siang-Ming Tsai, Yi-Ping Fang, Wing-Cheung Law, Han-Lin Tsai, Jia-Ying Tsai, Hsuan-Ying Chen *,Bao-Tsan Ko*, Pei-Wen Cheng*, Chih-Kuang Chen*

November 2025

Chemical Engineering Journal

陳喧應

Polymerization and depolymerization of polyesters and polycarbonates using 1,1,3,3-tetramethyl guanidine as a catalyst for improved resource utilization

Rajiv Kamaraj, Tzu-Yu Lin, Mallemadugula Ravi Teja, Taoufik Ben Halima, Hsi-Ching Tseng, Shangwu Ding and  Hsuan-Ying Chen*

September 2025

RSC Sustainability

吳志中

7,4'-dimethoxy-3-hydroxyflavone, a protease-activated receptor 4 (PAR4) inhibitor with antioxidant activity, ameliorates diabetic endothelial dysfunction

Ju-Ying Tsai, Hui-Ching Hsu, Chi-Jung Tai, Chin-Chung Wu*

2025 Oct;182(19):4592-4610.

British Journal of Pharmacology

李偉鵬

Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy

Ying-Chi Chen#, Li-Chan Chang#, Yan-Ling Liu#, Ming-Che Chang, Yin-Fen Liu, Po-Ya Chang, Divinah Manoharan, Wen-Jyun Wang, Jia-Sin Chen, Hsueh-Chun Wang, Wen-Tai Chiu*, Wei-Peng Li*, Hwo-Shuenn Sheu*, Wen-Pin Su*, and Chen-Sheng Yeh*.

2025 Apr 5;16(1):3253.

Nature Communications

李偉鵬

Serine-Grafted Cu2O Electrode Enabling Specific β-Hydroxybutyrate Detection by Surface Sensitization-Promoted Electrolysis in Amperometry

Ting-Chi Lo, Wen-Jyun Wang, Chih-Yen Chen*, Jui-Cheng Chang*, and Wei-Peng Li*.

2025 May 20;41(19):12022-12029.

Langmuir

李偉鵬

Water-Driven Oxygen and Nitric Oxide Release from Porphyrin- and Mn-Based Metal–Organic Framework Enables Accelerated Acute Wound Healing

Jieh-Neng Wang, Zih-Yu Tu, Wen-Jyun Wang, Wei-Peng Li*, Wei-Ling Chen*, and Chung-Dann Kan*.

2025 Sep 15;8(9):7616-7627.

ACS Applied Bio Materials

陳宜芳

Dual activation of AhR and Nrf2 pathways by the natural stilbenoid tapinarof protects against particulate matter-induced skin barrier dysfunction.

Chia-Hsuan Lin#, Horng-Huey Ko#, Jin-Ye Wu, Hsun-Shuo Chang , Chia-Hung Yen, Chien-Chih Chiu, Yih-Fung Chen*

2025 Sep 11:505:117559.

Toxicology and Applied Pharmacology

柯宏慧

Optimizing cinnamophilin delivery via SNEDDS for enhanced anti-melanogenic activity: A comprehensive evaluation of skin safety, permeability, and tyrosinase inhibition.

Yu-Chen Chen, Yih-Fung Chen, Hsin-Ya Yu, Chia-Hsuan Lin, Wan-Yi Liu, Hsun-Shuo Chang, Yu-Tse Wu*, Horng-Huey Ko*

2025 Nov 30:685:126260.

International Journal of Pharmaceutics

張訓碩

Flavonoid-sesquiterpenoid hybrids from the leaves of Syzygium simile and their anti-lipid droplet accumulation activities

Ching-Ju Yang, Yu-Chun Lin, Ho-Cheng Wu, Chia-Hung Yen, Chu-Hung Lin, Yueh-Hsiung Kuo, Hsun-Shuo Chang*

2025 Apr 25;88(4):1057-1067.

Journal of Natural Products

陳瑩容

Royal Jelly Extracellular Vesicles Enhance Diabetic Wound Healing via Inflammation Modulation, Fibroblast Migration, and Angiogenesis

Yen-Yu Tsai, Long-Sen Chang, Chun-Wen Lan, Ying-Jung Chen*, Jen-Hao Yang*

2025 Oct 22:20:12767-12781.

International Journal of Nanomedicine

王俊棋

Carbon nanomaterials in nucleic acid diagnostics: Advances in sensing and amplification

Po-Tsang Huang, Tsai-Hui Duh, Yen-Ling Chen, Yi-Hui Lin, Chun-Chi Wang*

July 2025

Microchemical Journal

王俊棋

Novel Primer Design for Significantly Reducing Fluorescent Interferences in the Synthesis of DNA-Templated Copper Nanoclusters for the Detection of the HLA-B*5801 Gene

Ke-Peng Lai, Bo-Yu Liu, Wei-Lung Tseng, Hwang-Shang Kou, Chun-Chi Wang*

2025 Apr 25;10(4):2609-2616.

ACS Sensors

陳秀蘭

Intermittent Hypoxia Triggers Glial Cell Activation,
GluN2B Receptor Upregulation and Hyperalgesia in
a Mouse Model of Sleep Apnea

Yen-Chin Liu, Bo-Ya Chiu, Kuan-Yi Tu, I-Chen Liu, Shiou-Lan Chen*

2025 Jul;29(6):e70039.

European Journal of Pain

陳秀蘭

Intermittent Hypoxia Damages Tyrosine Hydroxylase-Containing
Neurons in the Substantia Nigra and Locus Coeruleus but Not Hippocampal Neurons in Male Mouse Models of Early-Stage Sleep Apnea

Chia-Hui Chu, Yueh-Ching Chang,Kuang-Ting Liu,Yen-Chin Liu, Mei-Chuan Chou, Ching-Kuan Liu,Chu-Huang Chen, Junn-Liang Chang*, | Shiou-Lan Chen*

2025 Jun;103(6):e70050.

Journal Of Neuroscience Research

顏峰霖

Assessment of skin safety and anti-pollution activity of Clitoria ternatea L. (butterfly pea) flower extract

Hsuan Fu, Chun-Yin Yang, Pamela Berilyn So, Chia-Hung Yen, Tzu-Hui Wu*, Feng-Lin Yen*

2026 Feb 10:356:120739.

Journal Of Ethnopharmacology

謝雅茹

Transmucosal Delivery of miR-30c-5p by Chitosan
Nanoparticles for Oral Squamous Cell Carcinoma

Yi-Ping Fang, Yu-Chih Lin, Chien-Yu Lin, Po-Jen Wang, Ting-Yu Chang, Ya-Ju Hsieh*

2025 Jul 19:20:9179-9194.

Iinternational Journal Of Nanomedicine

林韋佑

Activation of gem-Dichloroacetamides and Epoxides Using Elemental Sulfur and Amines: A Route to Monothiooxalamides and α-Ketothioamide

Alageswaran Jayaram, Yu-Ming Liu, Nian-Qi Chen, Genin Gary Huang, Gopal Chandru Senadi, Wei-Yu Lin*

2025 Oct 17;90(41):14673-14682.

The Journal of Organic Chemistry

袁行修

Oncogenic role of fumarate hydratase in breast cancer: metabolic reprogramming and mechanistic insights

Shyng‑Shiou F.* Yuan, Anupama Vadhan, Hieu D. H. Nguyen, Pang‑Yu Chen, Chih‑Huang Tseng, Ching‑Hu Wu,Yu‑Chieh Chen, Yi‑Chia Wu, Stephen Chu‐Sung Hu, Steven Lo, Ming‑Feng Hou and Yen‑Yun Wang*

2025 May 29;13(1):26.

Cancer & Metabolism

袁行修

Copper-nitrite complexes release nitric oxide and selectively induce oral precancer and cancer cell apoptosis

Yen-Yun Wang, Pang-Yu Chend, Naorem Jemes Meiteie, Yu-Ren Lina, Tsai-Te Luf,  Hieu D.H. Nguyena, Sodio C.N. Hsu*, Shyng-Shiou F. Yuan*

2025 Apr:265:112833.

Journal of Inorganic Biochemistry

蔡維中

Atrial arrhythmogenesis and electrophysiological remodeling in hypokalaemic metabolic syndrome: the role of apamin-sensitive SK channels.

Kuo CH, Shih JY, Lin YH, Chang CW, Jhuo SJ, Lin TC, Huang TC, Liu IH, Kao PH, Lin EY, Huang PC, Chen XH, Chen CY, Feng YC, Zheng YX, Lin MH, Chen GL, Hsu PC, Lee CH, Wu CC, Lee HC, Wu BN, Lin SF, Lai WT, Tsai WC*.

2025 Aug 4;27(8):euaf159.

Europace

蔡維中

Higher skin sympathetic nerve activity as a potential predictor of overactive bladder in females refractory to oral monotherapy

Yu-Chen Chen, Hao-Wei Chen, Tien-Chi Huang, Chien-Hung Lee, Ting-Yin Chu*, Yung-Shun Juan, Yu-Peng Liu, Wei-Chung Tsai*, Wen-Jeng Wu*

2024 Nov;40(11):1020-1028.

Kaohsiung Journal of Medical Sciences

李建興

Oleanolic acid activates the JNK‑Sp1‑DJ‑1 axis to promote
mitophagy‑mediated neuroprotection in dopaminergic neurons
for Parkinson’s disease treatment

Han‑Bin Yang#, Chien‑Hsing Lee#, Nguyen Thao Nhung
, Shih‑Ya Hung*

2025 Jun;48(6):528-548.

Archives of Pharmacal Research

李建興

A New Sesquiterpenoid of Curcuma longa.

Chang, K. E.; Kao, C. L.; Huang, S. T.; Cheng, M. J.; Li, H. T.; Li, W. J.*; Chen, C. Y.*; Hsu, J. L.*; Lee, C. H.*

September 2025

Chemistry of Natural Compounds

林文瑋

Genetically engineered secretory horseradish peroxidase is a sensitive, stable, and affordable non-lytic reporter gene system for real-time promoter activity management

Chang, Mu-Shen; Lee, Chia-Yi; Chang, Yu-Yen; Li, Pin-Jie; Wu, Hsin-Yu; Liu, En-Shuo; Huang, Hsin-Kai; Lin, Wen-Wei*

2025 Apr 22;19(1):37.

Journal of Biological Engineering

林文瑋

Protease-activated anti-Lewis Y antibody enhances selectivity and safety of glycan-targeting cancer therapy

Wen-Han Lee, Ying-Rou Shen, Bo-Cheng Huang, Kai-Wen Ho, Ching-Kuei Chen, Hsuan-Hui Wu, Yi-Hsuan Hsieh, Yun-Chi Lu, Yi-An Cheng, Yu-Chi Lee, Shih-Ting Hong, Tzu-Yi Liao, Chia-Chun Chang, Liang-Yirn Liu, Mei-Chun Yang, Tong-Hsuan Chang, Tian-Lu Cheng, Yen-Ying Chen*, Wen-Wei Lin*

2025 May;309(Pt 4):143176.

International Journal of Biological Macromolecules

陳巧雲

Construction of in situ modulated controlled growth of MOF-on-mof impedimetric assembly for the practical minimal level assessment of anti-mullerian hormone

Wan-Zheng Fang, Sathyadevi Palanisamy, Priya Vijayaraghavan, Chiao-Yun Chen*, Shun-Long Weng, Chung-Shi Yang, Yun-Ming Wang*

2025 Mar 15:272:117113.


Biosensors & Bioelectronics

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